Studies have shown associations of birth weight with increased concentrations of high sensitivity C-reactive protein. GLOSSARY AHA = American Heart Association BP = blood pressure CDC = Centers for Disease Control and Prevention CI = confidence interval CRP = C-reactive protein CUMC = Columbia University Medical Center HR = hazard ratio hsCRP = high-sensitivity C-reactiveīirth weight, current anthropometric markers, and high sensitivity C-reactive protein in Brazilian school children. The value of hsCRP and serum amyloid A may depend on population characteristics such as age and other risk factors. Conclusion: In this multiethnic cohort, high-sensitivity C-reactive protein (hsCRP) was not associated with ischemic stroke, but was modestly associated with myocardial infarction and mortality. Compared with those with hsCRP 3 mg/L were at increased risk of ischemic stroke in a model adjusted for demographics (HR = 1.60, 95% CI 1.06–2.41), but the effect was attenuated after adjusting for other risk factors (adjusted HR = 1.20, 95% CI 0.78– 1.86). Results: hsCRP measurements were available in 2,240 participants (mean age 68.9 ± 10. Cox proportional hazards models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) for the association of markers with risk of ischemic stroke and other outcomes after adjusting for demographics and risk factors. hsCRP and SAA were measured using nephelometry. Methods: The Northern Manhattan Study includes a stroke-free community-based cohort study in participants aged ≥40 years (median follow-up 7.9 years). Their association with stroke is controversial. Background: Markers of inflammation have been associated with risk of myocardial infarction (MI). Objective: To determine whether high-sensitivity C-reactive protein (hsCRP) and serum amyloid A (SAA) predict stroke, vascular events, and mortality in a prospective cohort study. High-sensitivity C-reactive protein predicts mortality but not strokeĮlkind, M S.V. Conclusion Although high-sensitivity C-reactive protein was not predictive of combined major cardiovascular events within 30 days after ST-elevation myocardial infarction in patients who underwent primary angioplasty and stent However, high-sensitivity C-reactive protein was independently associated with 30-day mortality when adjusted for TIMI and GRACE (OR, 1.26 95% CI, 1.06-1.49 p = 0.007) risk scores. No statistically significant association was observed between high-sensitivity C-reactive protein and recurrent MACE (p = 0.11). Results The mean age was 59.76 years, and 69.3% of patients were male. P values of ≤0.05 were considered statistically significant. Student's t, Mann-Whitney, chi-square, and logistic regression tests were used for statistical analyses. The patients were followed-up during hospitalization and up to 30 days after infarction for the occurrence of MACE. High-sensitivity C-reactive protein was determined by nephelometry. An instrument evaluating clinical variables and the Thrombolysis in Myocardial Infarction (TIMI) and Global Registry of Acute Coronary Events (GRACE) risk scores was used. Methods This prospective cohort study included 300 individuals aged >18 years who were diagnosed with ST-elevation myocardial infarction and underwent primary percutaneous coronary intervention at a tertiary health center. Objective To investigate the potential association between high-sensitivity C-reactive protein and an increased risk of MACE such as death, heart failure, reinfarction, and new revascularization in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention.
Ribeiro, Daniel Rios Pinto Ramos, Adriane Monserrat Vieira, Pedro Lima Menti, Eduardo Bordin, Odemir Luiz de Souza, Priscilla Azambuja Lopes de Quadros, Alexandre Schaan Portal, Vera Lúciaīackground The association between high-sensitivity C-reactive protein and recurrent major adverse cardiovascular events (MACE) in patients with ST-elevation myocardial infarction who undergo primary percutaneous coronary intervention remains controversial. High-Sensitivity C-Reactive Protein as a Predictor of Cardiovascular Events after ST-Elevation Myocardial Infarction